Browsing by Person "Babor, Majharulislam"

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Online process state estimation for Hansenula polymorpha cultivation with 2D fluorescence spectra-based chemometric model calibrated from a theoretical model in place of offline measurements
(2023) Babor, Majharulislam; Paquet-Durand, Olivier; Berg, Christoph; Büchs, Jochen; Hitzmann, Bernd
The use of 2D fluorescence spectra is a powerful, instantaneous, and highly accurate method to estimate the state of bioprocesses. The conventional approach for calibrating a chemometric model from raw spectra needs a large number of offline measurements from numerous runs, which is tedious, time-consuming, and error-prone. In addition, many process variables lack direct signal responses, which forces chemometric models to make predictions based on indirect responses. In order to predict glycerol and biomass concentrations online in batch cultivation of Hansenula polymorpha, this study substituted offline measurements with simulated values. The only data from cultivations needed to generate the chemometric model were the 2D fluorescence spectra, with the presumption that they contain sufficient information to characterize the process state at a measurement point. The remainder of the evaluation was carried out with the aid of a mathematical process model that describes the theoretical interferences between process variables in the system. It is shown that the process model parameters, including microbial growth rate, the yield of biomass from glycerol, and lag time can be determined from only the spectra by employing a model-based calibration (MBC) approach. The prediction errors for glycerol and biomass concentrations were 8.6% and 5.7%, respectively. An improved model-based calibration (IMBC) approach is presented that calibrates a chemometric model for only biomass. Biomass was predicted from a 2D fluorescence spectrum in new cultivations, and glycerol concentration was estimated from the process model utilizing predicted biomass as an input. By using this method, the prediction errors for glycerol and biomass were reduced to 5.2% and 4.7%, respectively. The findings indicate that model-based calibration, which can be carried out with only 2D fluorescence spectra gathered from prior runs, is an effective method for estimating the process state online.
Optimization of no-wait flowshop scheduling problem in bakery production with modified PSO, NEH and SA
(2021) Babor, Majharulislam; Senge, Julia; Rosell, Cristina M.; Rodrigo, Dolores; Hitzmann, Bernd
In bakery production, to perform a processing task there might be multiple alternative machines that have the same functionalities. Finding an efficient production schedule is challenging due to the significant nondeterministic polynomial time (NP)-hardness of the problem when the number of products, processing tasks, and alternative machines are higher. In addition, many tasks are performed manually as small and medium-size bakeries are not fully automated. Therefore, along with machines, the integration of employees in production planning is essential. This paper presents a hybrid no-wait flowshop scheduling model (NWFSSM) comprising the constraints of common practice in bakeries. The schedule of an existing production line is simulated to examine the model and is optimized by performing particle swarm optimization (PSO), modified particle swarm optimization (MPSO), simulated annealing (SA), and Nawaz-Enscore-Ham (NEH) algorithms. The computational results reveal that the performance of PSO is significantly influenced by the weight distribution of exploration and exploitation in a run time. Due to the modification to the acceleration parameter, MPSO outperforms PSO, SA, and NEH in respect to effectively finding an optimized schedule. The best solution to the real case problem obtained by MPSO shows a reduction of the total idle time (TIDT) of the machines by 12% and makespan by 30%. The result of the optimized schedule indicates that for small- and medium-sized bakery industries, the application of the hybrid NWFSSM along with nature-inspired optimization algorithms can be a powerful tool to make the production system efficient.