Newest publications
Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)
(2022) Berling-Ernst, Anika; Yahiaoui-Doktor, Maryam; Kiechle, Marion; Engel, Christoph; Lammert, Jacqueline; Grill, Sabine; Dukatz, R.; Rhiem, Kerstin; Baumann, F. T.; Bischoff, Stephan C.; Erickson, N.; Schmidt, Thorsten; Niederberger, Uwe; Siniatchkin, M.; Halle, Martin; Berling-Ernst, A.; Department of Prevention and Sports Medicine, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Yahiaoui-Doktor, M.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany; Kiechle, M.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Engel, C.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany; Lammert, J.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Grill, S.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Dukatz, R.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Rhiem, K.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany; Baumann, F. T.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany; Bischoff, S. C.; Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany; Erickson, N.; Comprehensive Cancer Center Ludwig Maximillian University (CCC LMU), University of Munich Clinic, Munich, Germany; Schmidt, T.; University Cancer Center Schleswig-Holstein (UCCSH), Kiel, Germany; Niederberger, U.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany; Siniatchkin, M.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany; Halle, M.; DZHK (German Centre for Cardiovascular Research), Munich, Germany
Physical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality. Therefore, we wanted to identify predictors of CPF (represented by peak oxygen uptake: VO2peak) in BRCA1/2 mutation carriers whose risk of developing BC is high. We used cross-sectional data from 68 BRCA1/2 germline mutation carrying women participating in the randomized, prospective, controlled clinical study LIBRE-1. Assessments included cardiopulmonary exercise testing, medical and lifestyle history plus socioeconomic status. Additionally, the participants completed a psychological questionnaire regarding their attitude, subjective norms, perceived behavior control and intention towards PA. A multivariate logistic regression model was used to identify predictors for participants reaching their age- and sex-adjusted VO2peak reference values. 22 participants (median age: 40 years, interquartile range (IQR) 33–46) were cancer-unaffected and 46 cancer-affected (median age: 44 years, IQR 35–50). The strongest predictor for reaching the reference VO2peak value was attitude towards PA (Odds Ratio 3.0; 95% Confidence Interval 1.3–8.4; p = 0.021). None of the other predictors showed a significant association. A positive attitude towards PA seems to be associated with VO2peak, which should be considered in developing therapeutic and preventive strategies.Trial registrations: NCT02087592; DRKS00005736.
Win-win opportunities combining high yields with high multi-taxa biodiversity in tropical agroforestry
(2022) Wurz, Annemarie; Tscharntke, Teja; Martin, Dominic Andreas; Osen, Kristina; Rakotomalala, Anjaharinony A. N. A.; Raveloaritiana, Estelle; Andrianisaina, Fanilo; Dröge, Saskia; Fulgence, Thio Rosin; Soazafy, Marie Rolande; Andriafanomezantsoa, Rouvah; Andrianarimisa, Aristide; Babarezoto, Fenohaja Soavita; Barkmann, Jan; Hänke, Hendrik; Hölscher, Dirk; Kreft, Holger; Rakouth, Bakolimalala; Guerrero-Ramírez, Nathaly R.; Ranarijaona, Hery Lisy Tiana; Randriamanantena, Romual; Ratsoavina, Fanomezana Mihaja; Raveloson Ravaomanarivo, Lala Harivelo; Grass, Ingo; Wurz, Annemarie; Conservation Ecology, Department of Biology, Philipps-University Marburg, Marburg, Germany; Tscharntke, Teja; Centre for Biodiversity and Sustainable Land Use (CBL), University of Göttingen, Göttingen, Germany; Martin, Dominic Andreas; Department of Geography, University of Zurich, Zürich, Switzerland; Osen, Kristina; Tropical Silviculture and Forest Ecology, University of Göttingen, Göttingen, Germany; Rakotomalala, Anjaharinony A. N. A.; Entomology Department Faculty of Science, University of Antananarivo, Antananarivo, Madagascar; Raveloaritiana, Estelle; Plant Biology and Ecology Department, University of Antananarivo, University of Antananarivo, Antananarivo, Madagascar; Andrianisaina, Fanilo; Department of Tropical Agriculture and Sustainable Development, Higher School of Agronomic Science,University of Antananarivo, Antananarivo, Madagascar; Dröge, Saskia; Division of Forest, Nature and Landscape, KU Leuven, Leuven, Belgium; Fulgence, Thio Rosin; Natural and Environmental Sciences, Regional University Centre of the SAVA Region (CURSA), Antalaha, Madagascar; Soazafy, Marie Rolande; Doctoral School of Natural Ecosystems (EDEN), University of Mahajanga, Mahajanga, Madagascar; Andriafanomezantsoa, Rouvah; Zoology and Animal Biodiversity, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar; Andrianarimisa, Aristide; Zoology and Animal Biodiversity, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar; Babarezoto, Fenohaja Soavita; Diversity Turn in Land Use Science, coordination office, Sambava, Madagascar; Barkmann, Jan; Department of Agricultural Economics and Rural Development, Research Unit Environmental- and Resource Economics, University of Göttingen, Göttingen, Germany; Hänke, Hendrik; Department of Agricultural Economics and Rural Development, Research Unit Environmental- and Resource Economics, University of Göttingen, Göttingen, Germany; Hölscher, Dirk; Tropical Silviculture and Forest Ecology, University of Göttingen, Göttingen, Germany; Kreft, Holger; Biodiversity, Macroecology and Biogeography, University of Göttingen, Göttingen, Germany; Rakouth, Bakolimalala; Plant Biology and Ecology Department, University of Antananarivo, University of Antananarivo, Antananarivo, Madagascar; Guerrero-Ramírez, Nathaly R.; Biodiversity, Macroecology and Biogeography, University of Göttingen, Göttingen, Germany; Ranarijaona, Hery Lisy Tiana; Doctoral School of Natural Ecosystems (EDEN), University of Mahajanga, Mahajanga, Madagascar; Randriamanantena, Romual; Natural and Environmental Sciences, Regional University Centre of the SAVA Region (CURSA), Antalaha, Madagascar; Ratsoavina, Fanomezana Mihaja; Zoology and Animal Biodiversity, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar; Raveloson Ravaomanarivo, Lala Harivelo; Entomology Department Faculty of Science, University of Antananarivo, Antananarivo, Madagascar; Grass, Ingo; Ecology of Tropical Agricultural Systems, University of Hohenheim, Stuttgart, Germany
Resolving ecological-economic trade-offs between biodiversity and yields is a key challenge when addressing the biodiversity crisis in tropical agricultural landscapes. Here, we focused on the relation between seven different taxa (trees, herbaceous plants, birds, amphibians, reptiles, butterflies, and ants) and yields in vanilla agroforests in Madagascar. Agroforests established in forests supported overall 23% fewer species and 47% fewer endemic species than old-growth forests, and 14% fewer endemic species than forest fragments. In contrast, agroforests established on fallows had overall 12% more species and 38% more endemic species than fallows. While yields increased with vanilla vine density and length, non-yield related variables largely determined biodiversity. Nonetheless, trade-offs existed between yields and butterflies as well as reptiles. Vanilla yields were generally unrelated to richness of trees, herbaceous plants, birds, amphibians, reptiles, and ants, opening up possibilities for conservation outside of protected areas and restoring degraded land to benefit farmers and biodiversity alike.
Consumption of yeast-fermented wheat and rye breads increases colitis and mortality in a mouse model of colitis
(2022) Zimmermann, Julia; De Fazio, Luigia; Kaden-Volynets, Valentina; Hitzmann, Bernd; Bischoff, Stephan C.; Zimmermann, Julia; Department of Nutritional Medicine/Prevention, University of Hohenheim, Stuttgart, Germany; De Fazio, Luigia; Department of Medical and Surgical Science (DIMEC), University of Bologna, Bologna, Italy; Kaden-Volynets, Valentina; Department of Nutritional Medicine/Prevention, University of Hohenheim, Stuttgart, Germany; Hitzmann, Bernd; Department of Process Analytics and Cereal Science, University of Hohenheim, Stuttgart, Germany; Bischoff, Stephan C.; Department of Nutritional Medicine/Prevention, University of Hohenheim, Stuttgart, Germany
Background: Cereals are known to trigger for wheat allergy, celiac disease and non-celiac wheat sensitivity (NCWS). Inflammatory processes and intestinal barrier impairment are suspected to be involved in NCWS, although the molecular triggers are unclear.
Aims: We were interested if different bread types influence inflammatory processes and intestinal barrier function in a mouse model of inflammatory bowel disease.
Methods: Epithelial caspase-8 gene knockout (Casp8 ΔIEC ) and control (Casp8 fl ) mice were randomized to eight groups, respectively. The groups received different diets for 28 days (gluten-free diet, gluten-rich diet 5 g%, or different types of bread at 50 g%). Breads varied regarding grain, milling and fermentation. All diets were isocaloric.
Results: Regardless of the diet, Casp8 ΔIEC mice showed pronounced inflammation in colon compared to ileum, whereas Casp8 fl mice were hardly inflamed. Casp8 fl mice could tolerate all bread types. Especially yeast fermented rye and wheat bread from superfine flour but not pure gluten challenge increased colitis and mortality in Casp8 ΔIEC mice. Hepatic expression of lipopolysaccharide-binding protein and colonic expression of tumor necrosis factor-α genes were inversely related to survival. The bread diets, but not the gluten-rich diet, also decreased colonic tight junction expression to variable degrees, without clear association to survival and inflammation.
Conclusions: Bread components, especially those from yeast-fermented breads from wheat and rye, increase colitis and mortality in Casp8 ΔIEC mice highly susceptible to intestinal inflammation, whereas control mice can tolerate all types of bread without inflammation. Yet unidentified bread components other than gluten seem to play the major role.
Lost in translation? Exploring the effects of multilingual packaging and foreign language communication on consumer behavior
(2024) Munz, Rafael; Hüttl-Maack, Verena
Globalization has increased the importance of foreign languages in marketing. Consumers encounter foreign languages in many ways, from reading translations on product packaging to using foreign language media. The ubiquity of foreign language information in peoples’ lives raises the question of how their presence and use influences consumer behavior. The objective of this dissertation was to examine the influence of foreign languages on consumer judgments. Specifically, it focused on multilingual and foreign language (marketing) stimuli. Multilingual stimuli provide translations into several languages, enabling consumers to access information in their native language. This dissertation addresses a research gap by examining how consumers are affected by the additional presence of multiple translations on packaging. In contrast, foreign language stimuli require the processing of content in a learned foreign language. Research has demonstrated that foreign language processing influences peoples’ judgments when confronted with moral dilemmas and unpleasant stimuli. This dissertation aimed to contribute to the explanation of the (moral) foreign language effect and to extend extant research onto the domain of consumer behavior. The first research paper examined the influence of multilingual packaging on consumer behavior. An initial field study confirmed the widespread use of multilingual packaging in the German retail sector. In three experimental studies (N = 3,010), two of which two were pre-registered, German native speakers were presented with images of multilingual packaging. The packages varied in terms of the number of translations and the consumers’ level of familiarity with the foreign languages. Across several product categories, it was demonstrated that foreign language presence can negatively affect the metacognitive processing experience. Specifically, a large number of translations reduced perceived fluency, meaning that processing was experienced as more effortful. Furthermore, consumers’ unfamiliarity with the foreign languages was identified as a driver of disfluency. The negative effects on fluency led to unfavorable downstream consequences on product evaluations and purchase intentions. Product type was identified as a boundary condition. Specifically, the observed effects were less pronounced for technical products. This moderating effect was attributed to consumers having lower fluency expectations for complex products .
The second paper investigated how processing in a learned foreign language changes the response toward (un)ethical corporate conduct. In two experimental studies, German native speakers with high English language proficiency (N = 356) were presented with information about (un)ethical corporate actions in either their native language or a learned foreign language. The study demonstrated that foreign language processing attenuates the emotional response. Consequently, unethical practices, such as child labor, evoked lower levels of negative emotions. Similarly, weaker positive emotions elicited by ethical company practices were observed. In turn, downstream consequences on behavioral intentions toward the company were weakened by foreign language use. In the third paper, the influence of foreign language processing on the response toward freedom-restricting instructions was examined. During the COVID-19 pandemic, individuals were frequently confronted with virus mitigation instructions (e.g., concerning the use of masks). In an experimental study (N = 605), it was demonstrated that foreign language processing of highly restrictive messages has a positive effect on individuals’ sense of control. Participants felt more capable of managing the situation they were faced with, which led to a positive effect on the behavioral intention to follow the instructions. This dissertation includes the first research to comprehensively analyze how individuals are affected by the presence of multiple translations. By uncovering negative effects on the metacognitive experience, it contributes to literature streams on packaging design, international marketing, and fluency. Furthermore, it provides recommendations for marketers tasked with developing multilingual marketing materials. The second and third papers contribute to literature on the foreign language effect. By demonstrating that foreign language processing affects perceptions of (un)ethical corporate behavior, the moral foreign language effect is extended to the area of consumer behavior. The final research novelly demonstrates that foreign language processing can positively influence individuals’ sense of control. The papers enable practitioners to more accurately predict their audiences’ response to foreign language communication. Finally, the dissertation discusses limitations and further avenues for research.
Vermischtes 43
(2021)