Browsing by Person "Rust, Petra"

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    A high sucrose detection threshold is associated with increased energy intake and improved post-prandial glucose response independent of the sweetness intensity of isocaloric sucrose solutions
    (2024) Preinfalk, Verena; Schweiger, Kerstin; Hüller, Leonie; Dunkel, Andreas; Kimmeswenger, Isabella; Deck, Corinna M.; Rust, Petra; Somoza, Veronika; Krammer, Gerhard E.; Ley, Jakob P.; Lieder, Barbara
    Several studies proposed a role for the sweet taste receptor in energy intake and blood glucose regulation, but little is yet known about the impact of the individual sweet taste perception. Here, we found in a cross-over human intervention study with 29 male participants that modulating the sweetness of an isocaloric sucrose solution did not influence postprandial plasma concentrations of blood glucose and associated hormones over 120 min and 2 h post-load energy intake. Independent of the sweetness of the test solution, tests persons with a higher sucrose detection threshold had an average of 402 ± 78.8 kcal (39 ± 21%) higher energy intake and a higher glucose/insulin ratio, combined with a higher liking for sweet tasting food, than the test persons of the low threshold group. The body composition suggested a higher fat-free mass in the high threshold group that may have influenced energy intake and post-prandial glucose responses.
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    Sucrose reduction with maintained sweetness level lowers glycemic fluctuations and energy intake in healthy males
    (2025) Gaider, Marlies; Kimmeswenger, Isabella; Schmidt, Jana; Thines, Cynthia; Wu, Anni; Stoffl, Teresa K.; Rust, Petra; Ley, Jakob P.; Krammer, Gerhard E.; Somoza, Veronika; Lieder, Barbara; Gaider, Marlies; Christian Doppler Laboratory for Taste Research, Faculty of Chemistry, University of Vienna, Vienna, Austria; Kimmeswenger, Isabella; Vienna Doctoral School of Chemistry (DoSChem), University of Vienna, Vienna, Austria; Schmidt, Jana; Department Human Nutrition and Dietetics, Institute of Clinical Nutrition, University of Hohenheim, Stuttgart, Germany; Thines, Cynthia; Christian Doppler Laboratory for Taste Research, Faculty of Chemistry, University of Vienna, Vienna, Austria; Wu, Anni; Christian Doppler Laboratory for Taste Research, Faculty of Chemistry, University of Vienna, Vienna, Austria; Stoffl, Teresa K.; Christian Doppler Laboratory for Taste Research, Faculty of Chemistry, University of Vienna, Vienna, Austria; Rust, Petra; Department of Nutrional Science, Faculty of Life Sciences, University of Vienna, Vienna, Austria; Ley, Jakob P.; Symrise AG, Holzminden, Germany; Krammer, Gerhard E.; Symrise AG, Holzminden, Germany; Somoza, Veronika; Institute of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Vienna, Austria
    Introduction: The sole perception of sweet taste is discussed to interfere with postprandial blood glucose regulation and leading to enhanced cravings for sweet foods. This raises the question whether preserving sweetness while reducing sugar in a test solution can sustain beneficial effects on blood glucose regulation and subsequently decrease postprandial energy intake. Specifically, we hypothesized that reducing the caloric load of a sucrose solution while maintaining the perceived sweetness intensity by adding hesperetin as a taste modifier attenuates large fluctuations in postprandial blood glucose concentrations with beneficial effects on appetite and cravings for sweet foods. Methods: In a randomized crossover study with 32 healthy male participants, the effect of a 10% sucrose solution on blood glucose regulation and energy intake was compared to an equi-sweet 7% sucrose solution with 50 mg/L hesperetin. Data was analyzed using paired Student’s t-tests or Repeated-measures ANOVA. The study was approved by the ethical committee of the University of Vienna (approval number 00903) and registered at ClinicalTrials.gov (NCT05705596). Results: The results show that the decline in blood glucose concentrations was less pronounced after consumption of the 7% sucrose solution with hesperetin than after the isosweet 10% sucrose solution. Additionally, participants reported less desire for a sweet snack and had on average a 10 ± 7% (p < 0.05) lower energy intake after consumption of the 7% sucrose hesperetin-spiked solution. Conclusion: In conclusion, our results argue for a pronounced role of the carbohydrate content in postprandial appetite regulation.