Antioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cells

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dc.contributor.authorNir, Dana
dc.contributor.authorRibarski-Chorev, Ivana
dc.contributor.authorShimoni, Chen
dc.contributor.authorStrauss, Carmit
dc.contributor.authorFrank, Jan
dc.contributor.authorSchlesinger, Sharon
dc.date.accessioned2024-09-03T14:03:54Z
dc.date.available2024-09-03T14:03:54Z
dc.date.issued2022de
dc.description.abstractMesenchymal stem cells (MSC) have many roles that are important for the body’s proper functioning. When the MSC pool is damaged, it is often correlated with impaired development or health of the organism. MSC are known for their anti-inflammatory, immunomodulatory and trophic characteristics that play an important role in the physiological homeostasis of many tissues. Heat shock impairs MSC capacity by inducing the generation of reactive oxygen species and mitochondrial dysfunction, which, in turn, send the cells into a state of premature senescence. Here, we pre-exposed MSC to melatonin, resveratrol, or curcumin, which are natural antioxidative compounds, and tested the protective effects of these substances from oxidative stress and aging. Our data showed that pre-exposure of MSC to antioxidants decreased reactive oxygen species while mitochondrial damage remained high. Additionally, although the proliferation of the cells was slow, antioxidants protected the cells from premature senescence, and subsequent cytokine release was prevented. We conclude that while elevated temperatures directly cause mitochondrial damage, senescence is induced by elevated ROS levels. We suggest that heat shock alters cell and tissue homeostasis by several independent mechanisms; however, reducing tissue senescence will reduce damage and provide a pathway to overcome physiological challenges in animals.en
dc.identifier.swb1806130831
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16615
dc.identifier.urihttps://doi.org/10.3390/ijms23105750
dc.language.isoengde
dc.rights.licensecc_byde
dc.source1422-0067de
dc.sourceInternational journal of molecular sciences; Vol. 23, No. 10 (2022) 5750de
dc.subjectAntioxidants
dc.subjectSenescence
dc.subjectHeat shock
dc.subjectMesenchymal stem cells
dc.subjectMelatonin
dc.subjectResveratrol
dc.subjectCurcumin
dc.subject.ddc570
dc.titleAntioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cellsen
dc.type.diniArticle
dcterms.bibliographicCitationInternational journal of molecular sciences, 23 (2022), 10, 5750. https://doi.org/10.3390/ijms23105750. ISSN: 1422-0067
dcterms.bibliographicCitation.issn1422-0067
dcterms.bibliographicCitation.issue10
dcterms.bibliographicCitation.journaltitleInternational journal of molecular sciences
dcterms.bibliographicCitation.volume23
local.export.bibtex@article{Nir2022, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16615}, doi = {10.3390/ijms23105750}, author = {Nir, Dana and Ribarski-Chorev, Ivana and Shimoni, Chen et al.}, title = {Antioxidants Attenuate Heat Shock Induced Premature Senescence of Bovine Mesenchymal Stem Cells}, journal = {International journal of molecular sciences}, year = {2022}, volume = {23}, number = {10}, }
local.export.bibtexAuthorNir, Dana and Ribarski-Chorev, Ivana and Shimoni, Chen et al.
local.export.bibtexKeyNir2022
local.export.bibtexType@article

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