Uncovering the relationship between selenium status, age, health, and dietary habits: Insights from a large population study including nonagenarian offspring from the MARK-AGE project

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dc.contributor.authorGiacconi, Robertina
dc.contributor.authorPiacenza, Francesco
dc.contributor.authorAversano, Valentina
dc.contributor.authorZampieri, Michele
dc.contributor.authorBürkle, Alexander
dc.contributor.authorVillanueva, María Moreno
dc.contributor.authorDollé, Martijn E.T.
dc.contributor.authorJansen, Eugène
dc.contributor.authorGrune, Tilman
dc.contributor.authorGonos, Efstathios S.
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorCapri, Miriam
dc.contributor.authorWeinberger, Birgit
dc.contributor.authorSikora, Ewa
dc.contributor.authorToussaint, Olivier
dc.contributor.authorDebacq-Chainiaux, Florence
dc.contributor.authorStuetz, Wolfgang
dc.contributor.authorSlagboom, Pieternella Eline
dc.contributor.authorBernhardt, Jürgen
dc.contributor.authorFernández-Sánchez, Maria Luisa
dc.contributor.authorProvinciali, Mauro
dc.contributor.authorMalavolta, Marco
dc.date.accessioned2024-09-03T08:18:57Z
dc.date.available2024-09-03T08:18:57Z
dc.date.issued2023de
dc.description.abstractAn inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation.en
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16259
dc.identifier.urihttps://doi.org/10.3390/nu15092182
dc.language.isoengde
dc.rights.licensecc_byde
dc.source2072-6643de
dc.sourceNutrients; Vol. 15, No. 9 (2023) 2182de
dc.subjectSelenium fractionation
dc.subjectPlasma selenium
dc.subjectLongevity
dc.subjectAging
dc.subjectInflammation
dc.subject.ddc610
dc.titleUncovering the relationship between selenium status, age, health, and dietary habits: Insights from a large population study including nonagenarian offspring from the MARK-AGE projecten
dc.type.diniArticle
dcterms.bibliographicCitationNutrients, 15 (2023), 9, 2182. https://doi.org/10.3390/nu15092182. ISSN: 2072-6643
dcterms.bibliographicCitation.issn2072-6643
dcterms.bibliographicCitation.issue9
dcterms.bibliographicCitation.journaltitleNutrients
dcterms.bibliographicCitation.volume15
local.export.bibtex@article{Giacconi2023, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16259}, doi = {10.3390/nu15092182}, author = {Giacconi, Robertina and Piacenza, Francesco and Aversano, Valentina et al.}, title = {Uncovering the relationship between selenium status, age, health, and dietary habits: Insights from a large population study including nonagenarian offspring from the MARK-AGE project}, journal = {Nutrients}, year = {2023}, volume = {15}, number = {9}, }
local.export.bibtexAuthorGiacconi, Robertina and Piacenza, Francesco and Aversano, Valentina et al.
local.export.bibtexKeyGiacconi2023
local.export.bibtexType@article

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