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Cognitive alterations in old mice are associated with intestinal barrier dysfunction and induced toll-like receptor 2 and 4 signaling in different brain regions

dc.contributor.authorBrandt, Annette
dc.contributor.authorKromm, Franziska
dc.contributor.authorHernández-Arriaga, Angélica
dc.contributor.authorMartínez Sánchez, Inés
dc.contributor.authorBozkir, Haktan Övül
dc.contributor.authorStaltner, Raphaela
dc.contributor.authorBaumann, Anja
dc.contributor.authorCamarinha-Silva, Amélia
dc.contributor.authorHeijtz, Rochellys Diaz
dc.contributor.authorBergheim, Ina
dc.date.accessioned2024-09-03T07:30:33Z
dc.date.available2024-09-03T07:30:33Z
dc.date.issued2023de
dc.description.abstractEmerging evidence implicate the ‘microbiota–gut–brain axis’ in cognitive aging and neuroinflammation; however, underlying mechanisms still remain to be elucidated. Here, we assessed if potential alterations in intestinal barrier function and microbiota composition as well as levels of two key pattern-recognition receptors namely Toll-like receptor (TLR) 2 and TLR4, in blood and different brain regions, and depending signaling cascades are paralleling aging associated alterations of cognition in healthy aging mice. Cognitive function was assessed in the Y-maze and intestinal and brain tissue and blood were collected in young (4 months old) and old (24 months old) male C57BL/6 mice to determine intestinal microbiota composition by Illumina amplicon sequencing, the concentration of TLR2 and TLR4 ligands in plasma and brain tissue as well as to determine markers of intestinal barrier function, senescence and TLR2 and TLR4 signaling. Cognitive function was significantly impaired in old mice. Also, in old mice, intestinal microbiota composition was significantly altered, while the relative abundance of Gram-negative or Gram-positive bacteria in the small and large intestines at different ages was not altered. Moreover, intestinal barrier function was impaired in small intestine of old mice, and the levels of TLR2 and TLR4 ligands were also significantly higher in both portal and peripheral blood. Furthermore, levels of TLR2 and TLR4 ligands, and downstream markers of TLR signaling were higher in the hippocampal and prefrontal cortex of old mice compared to young animals. Taken together, our results suggest that even in ‘healthy’ aging, cognitive function is impaired in mice going along with an increased intestinal translocation of TLR ligands and alterations of TLR signaling in several brain regions.en
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16218
dc.identifier.urihttps://doi.org/10.3390/cells12172153
dc.language.isoengde
dc.rights.licensecc_byde
dc.source2073-4409de
dc.sourceCells; Vol. 12, No. 17 (2023) 2153de
dc.subjectHippocampus
dc.subjectPathogen-associated molecular patterns
dc.subjectCognition
dc.subjectIntestinal barrier
dc.subjectPrefrontal cortex
dc.subjectAging
dc.subject.ddc610
dc.titleCognitive alterations in old mice are associated with intestinal barrier dysfunction and induced toll-like receptor 2 and 4 signaling in different brain regionsen
dc.type.diniArticle
dcterms.bibliographicCitationCells, 12 (2023), 17, 2153. https://doi.org/10.3390/cells12172153. ISSN: 2073-4409
dcterms.bibliographicCitation.issn2073-4409
dcterms.bibliographicCitation.issue17
dcterms.bibliographicCitation.journaltitleCells
dcterms.bibliographicCitation.volume12
local.export.bibtex@article{Brandt2023, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16218}, doi = {10.3390/cells12172153}, author = {Brandt, Annette and Kromm, Franziska and Hernández-Arriaga, Angélica et al.}, title = {Cognitive alterations in old mice are associated with intestinal barrier dysfunction and induced toll-like receptor 2 and 4 signaling in different brain regions}, journal = {Cells}, year = {2023}, volume = {12}, number = {17}, }
local.export.bibtexAuthorBrandt, Annette and Kromm, Franziska and Hernández-Arriaga, Angélica et al.
local.export.bibtexKeyBrandt2023
local.export.bibtexType@article

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