Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)
dc.contributor.author | Berling-Ernst, Anika | |
dc.contributor.author | Yahiaoui-Doktor, Maryam | |
dc.contributor.author | Kiechle, Marion | |
dc.contributor.author | Engel, Christoph | |
dc.contributor.author | Lammert, Jacqueline | |
dc.contributor.author | Grill, Sabine | |
dc.contributor.author | Dukatz, R. | |
dc.contributor.author | Rhiem, Kerstin | |
dc.contributor.author | Baumann, F. T. | |
dc.contributor.author | Bischoff, Stephan C. | |
dc.contributor.author | Erickson, N. | |
dc.contributor.author | Schmidt, Thorsten | |
dc.contributor.author | Niederberger, Uwe | |
dc.contributor.author | Siniatchkin, M. | |
dc.contributor.author | Halle, Martin | |
dc.contributor.corporate | Berling-Ernst, A.; Department of Prevention and Sports Medicine, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany | |
dc.contributor.corporate | Yahiaoui-Doktor, M.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany | |
dc.contributor.corporate | Kiechle, M.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany | |
dc.contributor.corporate | Engel, C.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany | |
dc.contributor.corporate | Lammert, J.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany | |
dc.contributor.corporate | Grill, S.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany | |
dc.contributor.corporate | Dukatz, R.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany | |
dc.contributor.corporate | Rhiem, K.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany | |
dc.contributor.corporate | Baumann, F. T.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany | |
dc.contributor.corporate | Bischoff, S. C.; Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany | |
dc.contributor.corporate | Erickson, N.; Comprehensive Cancer Center Ludwig Maximillian University (CCC LMU), University of Munich Clinic, Munich, Germany | |
dc.contributor.corporate | Schmidt, T.; University Cancer Center Schleswig-Holstein (UCCSH), Kiel, Germany | |
dc.contributor.corporate | Niederberger, U.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany | |
dc.contributor.corporate | Siniatchkin, M.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany | |
dc.contributor.corporate | Halle, M.; DZHK (German Centre for Cardiovascular Research), Munich, Germany | |
dc.date.accessioned | 2025-04-30T12:32:24Z | |
dc.date.available | 2025-04-30T12:32:24Z | |
dc.date.issued | 2022 | |
dc.date.updated | 2024-10-02T07:20:49Z | |
dc.description.abstract | Physical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality. Therefore, we wanted to identify predictors of CPF (represented by peak oxygen uptake: VO2peak) in BRCA1/2 mutation carriers whose risk of developing BC is high. We used cross-sectional data from 68 BRCA1/2 germline mutation carrying women participating in the randomized, prospective, controlled clinical study LIBRE-1. Assessments included cardiopulmonary exercise testing, medical and lifestyle history plus socioeconomic status. Additionally, the participants completed a psychological questionnaire regarding their attitude, subjective norms, perceived behavior control and intention towards PA. A multivariate logistic regression model was used to identify predictors for participants reaching their age- and sex-adjusted VO2peak reference values. 22 participants (median age: 40 years, interquartile range (IQR) 33–46) were cancer-unaffected and 46 cancer-affected (median age: 44 years, IQR 35–50). The strongest predictor for reaching the reference VO2peak value was attitude towards PA (Odds Ratio 3.0; 95% Confidence Interval 1.3–8.4; p = 0.021). None of the other predictors showed a significant association. A positive attitude towards PA seems to be associated with VO2peak, which should be considered in developing therapeutic and preventive strategies.Trial registrations: NCT02087592; DRKS00005736. | en |
dc.description.sponsorship | Open Access funding enabled and organized by Projekt DEAL. | |
dc.description.sponsorship | Deutsche Krebshilfe http://dx.doi.org/10.13039/501100005972 | |
dc.description.sponsorship | Technische Universität München (1025) | |
dc.identifier.uri | https://doi.org/10.1038/s41598-022-06913-1 | |
dc.identifier.uri | https://hohpublica.uni-hohenheim.de/handle/123456789/16678 | |
dc.language.iso | eng | |
dc.rights.license | cc_by | |
dc.subject | Breast cancer | |
dc.subject | Cardiopulmonary fitness | |
dc.subject | BRCA1/2 mutation carriers | |
dc.subject | Breast cancer prevention | |
dc.subject | VO2peak | |
dc.subject | Physical activity | |
dc.subject.ddc | 610 | |
dc.title | Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1) | en |
dc.type.dini | Article | |
dcterms.bibliographicCitation | Scientific reports, 12 (2022), 2907. https://doi.org/10.1038/s41598-022-06913-1. ISSN: 2045-2322 | |
dcterms.bibliographicCitation.issn | 2045-2322 | |
dcterms.bibliographicCitation.issue | 1 | |
dcterms.bibliographicCitation.journaltitle | Scientific Reports | |
dcterms.bibliographicCitation.originalpublishername | Nature Publishing Group UK | |
dcterms.bibliographicCitation.volume | 12 | |
local.export.bibtex | @article{Berling-Ernst2022, doi = {10.1038/s41598-022-06913-1}, author = {Berling-Ernst, A. and Yahiaoui-Doktor, M. and Kiechle, M. et al.}, title = {Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)}, journal = {Scientific Reports}, year = {2022}, volume = {12}, } | |
local.export.bibtexAuthor | Berling-Ernst, A. and Yahiaoui-Doktor, M. and Kiechle, M. et al. | |
local.export.bibtexKey | Berling-Ernst2022 | |
local.export.bibtexType | @article | |
local.subject.sdg | 3 | |
local.subject.sdg | 4 | |
local.subject.sdg | 5 | |
local.title.full | Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1) |