Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)

dc.contributor.authorBerling-Ernst, Anika
dc.contributor.authorYahiaoui-Doktor, Maryam
dc.contributor.authorKiechle, Marion
dc.contributor.authorEngel, Christoph
dc.contributor.authorLammert, Jacqueline
dc.contributor.authorGrill, Sabine
dc.contributor.authorDukatz, R.
dc.contributor.authorRhiem, Kerstin
dc.contributor.authorBaumann, F. T.
dc.contributor.authorBischoff, Stephan C.
dc.contributor.authorErickson, N.
dc.contributor.authorSchmidt, Thorsten
dc.contributor.authorNiederberger, Uwe
dc.contributor.authorSiniatchkin, M.
dc.contributor.authorHalle, Martin
dc.contributor.corporateBerling-Ernst, A.; Department of Prevention and Sports Medicine, School of Medicine, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany
dc.contributor.corporateYahiaoui-Doktor, M.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany
dc.contributor.corporateKiechle, M.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany
dc.contributor.corporateEngel, C.; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany
dc.contributor.corporateLammert, J.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany
dc.contributor.corporateGrill, S.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany
dc.contributor.corporateDukatz, R.; Department of Gynecology and Center for Hereditary Breast and Ovarian Cancer, University Hospital Rechts der Isar, Technical University of Munich (TUM), Munich, Germany
dc.contributor.corporateRhiem, K.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany
dc.contributor.corporateBaumann, F. T.; Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), University Hospital Cologne, Cologne, Nordrhein-Westfalen, Germany
dc.contributor.corporateBischoff, S. C.; Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
dc.contributor.corporateErickson, N.; Comprehensive Cancer Center Ludwig Maximillian University (CCC LMU), University of Munich Clinic, Munich, Germany
dc.contributor.corporateSchmidt, T.; University Cancer Center Schleswig-Holstein (UCCSH), Kiel, Germany
dc.contributor.corporateNiederberger, U.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany
dc.contributor.corporateSiniatchkin, M.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel, Germany
dc.contributor.corporateHalle, M.; DZHK (German Centre for Cardiovascular Research), Munich, Germany
dc.date.accessioned2025-04-30T12:32:24Z
dc.date.available2025-04-30T12:32:24Z
dc.date.issued2022
dc.date.updated2024-10-02T07:20:49Z
dc.description.abstractPhysical activity (PA) helps prevention and aftercare of sporadic breast cancer (BC), cardiopulmonary fitness (CPF) being an age-independent predictor of tumor-specific mortality. Therefore, we wanted to identify predictors of CPF (represented by peak oxygen uptake: VO2peak) in BRCA1/2 mutation carriers whose risk of developing BC is high. We used cross-sectional data from 68 BRCA1/2 germline mutation carrying women participating in the randomized, prospective, controlled clinical study LIBRE-1. Assessments included cardiopulmonary exercise testing, medical and lifestyle history plus socioeconomic status. Additionally, the participants completed a psychological questionnaire regarding their attitude, subjective norms, perceived behavior control and intention towards PA. A multivariate logistic regression model was used to identify predictors for participants reaching their age- and sex-adjusted VO2peak reference values. 22 participants (median age: 40 years, interquartile range (IQR) 33–46) were cancer-unaffected and 46 cancer-affected (median age: 44 years, IQR 35–50). The strongest predictor for reaching the reference VO2peak value was attitude towards PA (Odds Ratio 3.0; 95% Confidence Interval 1.3–8.4; p = 0.021). None of the other predictors showed a significant association. A positive attitude towards PA seems to be associated with VO2peak, which should be considered in developing therapeutic and preventive strategies.Trial registrations: NCT02087592; DRKS00005736.en
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL.
dc.description.sponsorshipDeutsche Krebshilfe http://dx.doi.org/10.13039/501100005972
dc.description.sponsorshipTechnische Universität München (1025)
dc.identifier.urihttps://doi.org/10.1038/s41598-022-06913-1
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16678
dc.language.isoeng
dc.rights.licensecc_by
dc.subjectBreast cancer
dc.subjectCardiopulmonary fitness
dc.subjectBRCA1/2 mutation carriers
dc.subjectBreast cancer prevention
dc.subjectVO2peak
dc.subjectPhysical activity
dc.subject.ddc610
dc.titlePredictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)en
dc.type.diniArticle
dcterms.bibliographicCitationScientific reports, 12 (2022), 2907. https://doi.org/10.1038/s41598-022-06913-1. ISSN: 2045-2322
dcterms.bibliographicCitation.issn2045-2322
dcterms.bibliographicCitation.issue1
dcterms.bibliographicCitation.journaltitleScientific Reports
dcterms.bibliographicCitation.originalpublishernameNature Publishing Group UK
dcterms.bibliographicCitation.volume12
local.export.bibtex@article{Berling-Ernst2022, doi = {10.1038/s41598-022-06913-1}, author = {Berling-Ernst, A. and Yahiaoui-Doktor, M. and Kiechle, M. et al.}, title = {Predictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)}, journal = {Scientific Reports}, year = {2022}, volume = {12}, }
local.export.bibtexAuthorBerling-Ernst, A. and Yahiaoui-Doktor, M. and Kiechle, M. et al.
local.export.bibtexKeyBerling-Ernst2022
local.export.bibtexType@article
local.subject.sdg3
local.subject.sdg4
local.subject.sdg5
local.title.fullPredictors of cardiopulmonary fitness in cancer-affected and -unaffected women with a pathogenic germline variant in the genes BRCA1/2 (LIBRE-1)

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