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Article
2025
Die Erweiterung des genetischen Codes als molekulare Prozesskontrolle
Die Erweiterung des genetischen Codes als molekulare Prozesskontrolle
Abstract (English)
Bioproduction of bioactive compounds on a large-scale poses challenges that require molecular strain engineering. By integrating the principle of genetic code expansion (GCE), the biosynthesis of the surfactin biosurfactant has been controlled in the production host Bacillus subtilis depending on the supply of a defined non-canonical amino acid. The regulation of this molecular process control has been transferred to high-cell-density fed-batch bioreactor procedures, allowing an initial upscaling.
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Biospektrum, 31 (2025), 6, 673-675.
https://doi.org/10.1007/s12268-025-2564-z.
ISSN: 1868-6249
Berlin/Heidelberg : Springer Berlin Heidelberg
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Hiller, E., Hermann, A., & Lilge, L. (2025). Die Erweiterung des genetischen Codes als molekulare Prozesskontrolle. Biospektrum, 31(6). https://doi.org/10.1007/s12268-025-2564-z
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German
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660 Chemical engineerin
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University bibliography
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Sustainable Development Goals
BibTeX
@article{Hiller2025,
doi = {10.1007/s12268-025-2564-z},
author = {Hiller, Eric and Hermann, Alexander and Lilge, Lars et al.},
title = {Die Erweiterung des genetischen Codes als molekulare Prozesskontrolle},
journal = {BIOspektrum},
year = {2025},
volume = {31},
number = {6},
pages = {673--675},
}