Association of Torquetenovirus Viremia with physical frailty and cognitive impairment in three independent European cohorts

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dc.contributor.authorGiacconi, Robertina
dc.contributor.authorLaffon, Blanca
dc.contributor.authorCosta, Solange
dc.contributor.authorTeixeira-Gomes, Armanda
dc.contributor.authorMaggi, Fabrizio
dc.contributor.authorMacera, Lisa
dc.contributor.authorSpezia, Pietro Giorgio
dc.contributor.authorPiacenza, Francesco
dc.contributor.authorBürkle, Alexander
dc.contributor.authorMoreno-Villanueva, María
dc.contributor.authorBonassi, Stefano
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorTeixeira, Joao Paulo
dc.contributor.authorDollé, Martijn E.T.
dc.contributor.authorRietman, M. Liset
dc.contributor.authorJansen, Eugène
dc.contributor.authorGrune, Tilman
dc.contributor.authorGonos, Efstathios S.
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorCapri, Miriam
dc.contributor.authorWeinberger, Birgit
dc.contributor.authorSikora, Ewa
dc.contributor.authorStuetz, Wolfgang
dc.contributor.authorToussaint, Olivier
dc.contributor.authorDebacq-Chainiaux, Florence
dc.contributor.authorHervonen, Antti
dc.contributor.authorHurme, Mikko
dc.contributor.authorSlagboom, P. Eline
dc.contributor.authorSchön, Christiane
dc.contributor.authorBernhardt, Jürgen
dc.contributor.authorBreusing, Nicolle
dc.contributor.authorPásaro, Eduardo
dc.contributor.authorMaseda, Ana
dc.contributor.authorLorenzo-López, Laura
dc.contributor.authorMillán-Calenti, José Carlos
dc.contributor.authorProvinciali, Mauro
dc.contributor.authorMalavolta, Marco
dc.date.accessioned2024-08-19T12:58:39Z
dc.date.available2024-08-19T12:58:39Z
dc.date.issued2023de
dc.description.abstractIntroduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty, and cognitive impairment. Methods: TTV viremia was measured in 1,131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7 ± 5.9 years), and then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail, and 141 nonfrail individuals (overall mean age: 77.5 ± 8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06–10.67, p < 0.0001) and cognitive impairment (OR: 3.49, 95% CI: 2.14–5.69, p < 0.0001) in the MARK-AGE population. The association between TTV DNA load and frailty status was confirmed in the Spanish cohort, while a slight association with cognitive impairment was observed (OR: 1.33; 95% CI: 1.000–1.773), only in the unadjusted model. No association between TTV load and frailty or cognitive impairment was found in the Portuguese sample, although a negative association between TTV viremia and MMSE score was observed in Spanish and Portuguese females. Conclusions: These findings demonstrate an association between TTV viremia and physical frailty, while the association with cognitive impairment was observed only in the younger population from the MARK-AGE study. Further research is necessary to clarify TTV’s clinical relevance in the onset and progression of frailty and cognitive decline in older individuals.en
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16124
dc.identifier.urihttps://doi.org/10.1159/000528169
dc.language.isoengde
dc.rights.licensecopyrightde
dc.source1423-0003de
dc.sourceGerontology; Vol. 69, No. 6 (2023), 684-693de
dc.subjectTorquetenovirus
dc.subjectCognitive impairment
dc.subjectPhysical frailty
dc.subjectAging
dc.subjectInflammation
dc.titleAssociation of Torquetenovirus Viremia with physical frailty and cognitive impairment in three independent European cohortsen
dc.type.diniArticle
dcterms.bibliographicCitationGerontology, 69 (2023), 6, 684-693. https://doi.org/10.1159/000528169. ISSN: 1423-0003
dcterms.bibliographicCitation.issn1423-0003
dcterms.bibliographicCitation.issue6
dcterms.bibliographicCitation.journaltitleGerontology
dcterms.bibliographicCitation.volume69
local.export.bibtex@article{Giacconi2023, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16124}, doi = {10.1159/000528169}, author = {Giacconi, Robertina and Laffon, Blanca and Costa, Solange et al.}, title = {Association of Torquetenovirus Viremia with Physical Frailty and Cognitive Impairment in Three Independent European Cohorts}, journal = {Gerontology}, year = {2023}, volume = {69}, number = {6}, }
local.export.bibtexAuthorGiacconi, Robertina and Laffon, Blanca and Costa, Solange et al.
local.export.bibtexKeyGiacconi2023
local.export.bibtexType@article

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