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Article
2024
Bacillus anthracis in South Africa, 1975–2013: are some lineages vanishing?
Bacillus anthracis in South Africa, 1975–2013: are some lineages vanishing?
Abstract (English)
The anthrax-causing bacterium Bacillus anthracis comprises the genetic clades A, B, and C. In the northernmost part (Pafuri) of Kruger National Park (KNP), South Africa, both the common A and rare B strains clades occur. The B clade strains were reported to be dominant in Pafuri before 1991, while A clade strains occurred towards the central parts of KNP. The prevalence of B clade strains is currently much lower as only A clade strains have been isolated from 1992 onwards in KNP. In this study 319 B. anthracis strains were characterized with 31-loci multiple-locus variable-number tandem repeat analysis (MLVA-31). B clade strains from soil ( n = 9) and a Tragelaphus strepsiceros carcass ( n = 1) were further characterised by whole genome sequencing and compared to publicly available genomes. The KNP strains clustered in the B clade before 1991 into two dominant genotypes. South African strains cluster into a dominant genotype A.Br.005/006 consisting of KNP as well as the other anthrax endemic region, Northern Cape Province (NCP), South Africa. A few A.Br.001/002 strains from both endemic areas were also identified. Subclade A.Br.101 belonging to the A.Br.Aust94 lineage was reported in the NCP. The B-clade strains seems to be vanishing, while outbreaks in South Africa are caused mainly by the A.Br.005/006 genotypes as well as a few minor clades such as A.Br.001/002 and A.Br.101 present in NCP. This work confirmed the existence of the rare and vanishing B-clade strains that group in B.Br.001 branch with KrugerB and A0991 KNP strains.
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BMC genomics, 25 (2024), 1, 742.
https://doi.org/10.1186/s12864-024-10631-5.
ISSN: 1471-2164
London : BioMed Central
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Lekota, K. E., Hassim, A., Ledwaba, M. B., Glover, B. A., Dekker, Edgar. H., van Schalkwyk, L. O., Rossouw, J., Beyer, W., Vergnaud, G., & van Heerden, H. (2024). Bacillus anthracis in South Africa, 1975–2013: are some lineages vanishing? BMC genomics, 25(1). https://doi.org/10.1186/s12864-024-10631-5
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English
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610 Medicine and health
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@article{Lekota2024,
doi = {10.1186/s12864-024-10631-5},
author = {Lekota, Kgaugelo Edward and Hassim, Ayesha and Ledwaba, Maphuti Betty et al.},
title = {Bacillus anthracis in South Africa, 1975–2013: are some lineages vanishing?},
journal = {BMC genomics},
year = {2024},
volume = {25},
number = {1},
}