A fast gas chromatography coupled with electron capture negative ion mass spectrometry in selected ion monitoring mode screening method for short‐chain and medium‐chain chlorinated paraffins

dc.contributor.authorSchweizer, Sina
dc.contributor.authorSchulz, Tobias
dc.contributor.authorVetter, Walter
dc.date.accessioned2024-09-03T13:38:12Z
dc.date.available2024-09-03T13:38:12Z
dc.date.issued2022de
dc.description.abstractRationale Chlorinated paraffins (CPs) are a group of anthropogenic pollutants that consist of complex mixtures of polychlorinated n-alkanes of different chain lengths (~C10 to C30). Persistence, bioaccumulation, toxicity, and long-range transport of short-chain chlorinated paraffins (SCCPs, C10- to C13-CPs) have prompted their classification as persistent organic pollutants (POPs) by the Stockholm Convention in 2017. Due to the varying chain lengths and chlorination degrees, quantification of SCCPs and medium-chain chlorinated paraffins (MCCPs, C14- to C17) using gas chromatography coupled with electron capture negative ion mass spectrometry in selected ion monitoring mode (GC/ECNI-MS-SIM) is not only challenging but also very time consuming. In particular, up to eight GC runs per sample are required for the comprehensive GC/ECNI-MS-SIM quantification of SCCPs and MCCPs. These efforts are high especially if the samples do not contain CPs above the limit of detection (LOD), subsequently. Methods We developed a semi-quantitative and sensitive method for the examination of SCCPs and MCCPs in one GC run. This GC/ECNI-MS-SIM screening method was based on the recording of Cl− (m/z 35 and 37), Cl2− (m/z 70 and 72), and HCl2− (m/z 71 and 73) isotope ions and evaluation of the ratios between them. Results Correctness of the results of the screening method was verified by analysis of edible oils with and without CPs, CP standards, as well as a technical CP mixture. Polychlorinated biphenyls (PCBs) and other polyhalogenated aromatic compounds, as well as brominated flame retardants, do not form all of the fragment ions analyzed by the screening method. Conclusions After the screening, only CP-positive samples may need to be measured in detail. Measurement time will already be gained in the case of ~10% samples without CPs. en
dc.identifier.swb1815468564
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16538
dc.identifier.urihttps://doi.org/10.1002/rcm.9382
dc.language.isoengde
dc.rights.licensecc_by-nc-ndde
dc.source1097-0231de
dc.sourceRapid communications in mass spectrometry; Vol. 36, No. 22 (2022) e9382de
dc.subjectChlorinated Paraffins
dc.subjectGas Chromatography
dc.subject.ddc540
dc.titleA fast gas chromatography coupled with electron capture negative ion mass spectrometry in selected ion monitoring mode screening method for short‐chain and medium‐chain chlorinated paraffinsen
dc.type.diniArticle
dcterms.bibliographicCitationRapid communications in mass spectrometry, 36 (2022), 22, e9382. https://doi.org/10.1002/rcm.9382. ISSN: 1097-0231
dcterms.bibliographicCitation.issn1097-0231
dcterms.bibliographicCitation.issue22
dcterms.bibliographicCitation.journaltitleRapid communications in mass spectrometry
dcterms.bibliographicCitation.volume36
local.export.bibtex@article{Schweizer2022, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16538}, doi = {10.1002/rcm.9382}, author = {Schweizer, Sina and Schulz, Tobias and Vetter, Walter et al.}, title = {A fast gas chromatography coupled with electron capture negative ion mass spectrometry in selected ion monitoring mode screening method for short‐chain and medium‐chain chlorinated paraffins}, journal = {Rapid communications in mass spectrometry}, year = {2022}, volume = {36}, number = {22}, }
local.export.bibtexAuthorSchweizer, Sina and Schulz, Tobias and Vetter, Walter et al.
local.export.bibtexKeySchweizer2022
local.export.bibtexType@article

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