Dietary intake of fructooligosaccharides protects against metabolic derangements evoked by chronic exposure to fructose or galactose in rats

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dc.contributor.authorAlmasri, Fidèle
dc.contributor.authorCollotta, Debora
dc.contributor.authorAimaretti, Eleonora
dc.contributor.authorSus, Nadine
dc.contributor.authorAragno, Manuela
dc.contributor.authorDal Bello, Federica
dc.contributor.authorEva, Carola
dc.contributor.authorMastrocola, Raffaella
dc.contributor.authorLandberg, Rikard
dc.contributor.authorFrank, Jan
dc.contributor.authorCollino, Massimo
dc.date.accessioned2024-08-19T12:58:27Z
dc.date.available2024-08-19T12:58:27Z
dc.date.issued2023de
dc.description.abstractScope: Diets rich in fat and sugars evoke chronic low-grade inflammation, leading to metabolic derangements. This study investigates the impact of fructose and galactose, two commonly consumed simple sugars, on exacerbation of the harmful effects caused by high fat intake. Additionally, the potential efficacy of fructooligosaccharides (FOS), a fermentable dietary fiber, in counteracting these effects is examined. Methods and results: Male Sprague-Dawley rats (six/group) are fed 8 weeks as follows: control 5% fat diet (CNT), 20% fat diet (FAT), FAT+10% FOS diet (FAT+FOS), FAT+25% galactose diet (FAT+GAL), FAT+GAL+10% FOS diet (FAT+GAL+FOS), FAT+25% fructose diet (FAT+FRU), FAT+FRU+10% FOS diet (FAT+FRU+FOS). The dietary manipulations tested do not affect body weight gain, blood glucose, or markers of systemic inflammation whereas significant increases in plasma concentrations of triacylglycerols, cholesterol, aspartate aminotransferase, and alanine aminotrasferase are detected in both FAT+FRU and FAT+GAL compared to CNT. In the liver and skeletal muscle, both sugars induce significant accumulation of lipids and advanced glycation end-products (AGEs). FOS supplementation prevents these impairments. Conclusion: This study extends the understanding of the deleterious effects of a chronic intake of simple sugars and demonstrates the beneficial role of the prebiotic FOS in dampening the sugar-induced metabolic impairments by prevention of lipid and AGEs accumulation. en
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16085
dc.identifier.urihttps://doi.org/10.1002/mnfr.202300476
dc.language.isoengde
dc.rights.licensecc_by-nc-ndde
dc.source1613-4133de
dc.sourceMolecular Nutrition & Food Research; Vol. 68, No. 4 (2023) 2300476de
dc.subjectAdvanced glycation end‐productsen
dc.subjectBlood lipidsen
dc.subjectCytokinesen
dc.subjectInflammationen
dc.subjectLiver lipid accumulationen
dc.subject.ddc610
dc.titleDietary intake of fructooligosaccharides protects against metabolic derangements evoked by chronic exposure to fructose or galactose in ratsen
dc.type.diniArticle
dcterms.bibliographicCitationMolecular nutrition and food research, 68 (2023), 4, 2300476. https://doi.org/10.1002/mnfr.202300476. ISSN: 1613-4133
dcterms.bibliographicCitation.issn1613-4133
dcterms.bibliographicCitation.issue4
dcterms.bibliographicCitation.journaltitleMolecular nutrition and food research
dcterms.bibliographicCitation.volume68
local.export.bibtex@article{Almasri2023, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16085}, doi = {10.1002/mnfr.202300476}, author = {Almasri, Fidèle and Collotta, Debora and Aimaretti, Eleonora et al.}, title = {Dietary intake of fructooligosaccharides protects against metabolic derangements evoked by chronic exposure to fructose or galactose in rats}, journal = {Molecular nutrition and food research}, year = {2023}, volume = {68}, number = {4}, }
local.export.bibtexAuthorAlmasri, Fidèle and Collotta, Debora and Aimaretti, Eleonora et al.
local.export.bibtexKeyAlmasri2023
local.export.bibtexType@article

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