Association between vitamin D status and eryptosis - results from the German National Cohort Study

dc.contributor.authorEwendt, Franz
dc.contributor.authorSchmitt, Marvin
dc.contributor.authorKluttig, Alexander
dc.contributor.authorKühn, Julia
dc.contributor.authorHirche, Frank
dc.contributor.authorKraus, Frank B.
dc.contributor.authorLudwig-Kraus, Beatrice
dc.contributor.authorMikolajczyk, Rafael
dc.contributor.authorWätjen, Wim
dc.contributor.authorBürkner, Paul-Christian
dc.contributor.authorFöller, Michael
dc.contributor.authorStangl, Gabriele I.
dc.contributor.corporateEwendt, Franz; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
dc.contributor.corporateSchmitt, Marvin; Cluster of Excellence SimTech, University of Stuttgart, Stuttgart, Germany
dc.contributor.corporateKluttig, Alexander; Institute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
dc.contributor.corporateKühn, Julia; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
dc.contributor.corporateHirche, Frank; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
dc.contributor.corporateKraus, Frank B.; Central Laboratory, Department of Laboratory Medicine, University Hospital Halle, Halle (Saale), Germany
dc.contributor.corporateLudwig-Kraus, Beatrice; Central Laboratory, Department of Laboratory Medicine, University Hospital Halle, Halle (Saale), Germany
dc.contributor.corporateMikolajczyk, Rafael; Institute of Medical Epidemiology, Biostatistics, and Informatics, Medical Faculty of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
dc.contributor.corporateWätjen, Wim; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
dc.contributor.corporateBürkner, Paul-Christian; Cluster of Excellence SimTech, University of Stuttgart, Stuttgart, Germany
dc.contributor.corporateFöller, Michael; Department of Physiology, University of Hohenheim, Stuttgart, Germany
dc.contributor.corporateStangl, Gabriele I.; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
dc.date.accessioned2025-03-21T16:27:45Z
dc.date.available2025-03-21T16:27:45Z
dc.date.issued2023
dc.date.updated2024-12-02T06:44:30Z
dc.description.abstractVitamin D, besides its classical effect on mineral homeostasis and bone remodeling, can also modulate apoptosis. A special form of apoptosis termed eryptosis appears in erythrocytes. Eryptosis is characterized by cell shrinkage, membrane blebbing, and cell membrane phospholipid disorganization and associated with diseases such as sepsis, malaria or iron deficiency, and impaired microcirculation. To our knowledge, this is the first study that linked vitamin D with eryptosis in humans. This exploratory cross-sectional trial investigated the association between the vitamin D status assessed by the concentration of plasma 25-hydroxyvitamin D (25(OH)D) and eryptosis. Plasma 25(OH)D was analyzed by LC–MS/MS, and eryptosis was estimated from annexin V-FITC-binding erythrocytes by FACS analysis in 2074 blood samples from participants of the German National Cohort Study. We observed a weak but clear correlation between low vitamin D status and increased eryptosis ( r  =  − 0.15; 95% CI [− 0.19, − 0.10]). There were no differences in plasma concentrations of 25(OH)D and eryptosis between male and female subjects. This finding raises questions of the importance of vitamin D status for eryptosis in terms of increased risk for anemia or cardiovascular events.en
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL.
dc.description.sponsorshipDeutsche Stiftung für Herzforschung http://dx.doi.org/10.13039/501100005970
dc.description.sponsorshipDeutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659
dc.description.sponsorshipCyber Valley Research Fund
dc.description.sponsorshipMartin-Luther-Universität Halle-Wittenberg (1043)
dc.identifier.urihttps://doi.org/10.1007/s00277-023-05239-w
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/17059
dc.language.isoeng
dc.rights.licensecc_by
dc.subjectApoptosis
dc.subjectRed blood cells
dc.subject25-Hydroxyvitamin D
dc.subjectAnemia
dc.subjectCardiovascular risk
dc.subject.ddc610
dc.titleAssociation between vitamin D status and eryptosis - results from the German National Cohort Studyen
dc.type.diniArticle
dcterms.bibliographicCitationAnnals of hematology, 102 (2023), 6, 1351-1361. https://doi.org/10.1007/s00277-023-05239-w. ISSN: 1432-0584 ISSN: 0939-5555
dcterms.bibliographicCitation.issn0939-5555
dcterms.bibliographicCitation.issn1432-0584
dcterms.bibliographicCitation.issue6
dcterms.bibliographicCitation.journaltitleAnnals of Hematology
dcterms.bibliographicCitation.originalpublishernameSpringer Berlin Heidelberg
dcterms.bibliographicCitation.pageend1361
dcterms.bibliographicCitation.pagestart1351
dcterms.bibliographicCitation.volume102
local.export.bibtex@article{Ewendt2023, doi = {10.1007/s00277-023-05239-w}, author = {Ewendt, Franz and Schmitt, Marvin and Kluttig, Alexander et al.}, title = {Association between vitamin D status and eryptosis–results from the German National Cohort Study}, journal = {Annals of hematology}, year = {2023-05-01}, volume = {102}, number = {6}, pages = {1351--1361}, }
local.export.bibtexAuthorEwendt, Franz and Schmitt, Marvin and Kluttig, Alexander et al.
local.export.bibtexKeyEwendt2023-05-01
local.export.bibtexPages1351--1361
local.export.bibtexType@article

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