Multi-omics reveals different strategies in the immune and metabolic systems of high-yielding strains of laying hens

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dc.contributor.authorIqbal, Muhammad Arsalan
dc.contributor.authorReyer, Henry
dc.contributor.authorOster, Michael
dc.contributor.authorHadlich, Frieder
dc.contributor.authorTrakooljul, Nares
dc.contributor.authorPerdomo-Sabogal, Alvaro
dc.contributor.authorSchmucker, Sonja
dc.contributor.authorStefanski, Volker
dc.contributor.authorRoth, Christoph
dc.contributor.authorCamarinha Silva, Amélia
dc.contributor.authorHuber, Korinna
dc.contributor.authorSommerfeld, Vera
dc.contributor.authorRodehutscord, Markus
dc.contributor.authorWimmers, Klaus
dc.contributor.authorPonsuksili, Siriluck
dc.date.accessioned2024-10-23T12:25:50Z
dc.date.available2024-10-23T12:25:50Z
dc.date.issued2022de
dc.description.abstractLohmann Brown (LB) and Lohmann Selected Leghorn (LSL) are two commercially important laying hen strains due to their high egg production and excellent commercial suitability. The present study integrated multiple data sets along the genotype-phenotype map to better understand how the genetic background of the two strains influences their molecular pathways. In total, 71 individuals were analyzed (LB, n = 36; LSL, n = 35). Data sets include gut miRNA and mRNA transcriptome data, microbiota composition, immune cells, inositol phosphate metabolites, minerals, and hormones from different organs of the two hen strains. All complex data sets were pre-processed, normalized, and compatible with the mixOmics platform. The most discriminant features between two laying strains included 20 miRNAs, 20 mRNAs, 16 immune cells, 10 microbes, 11 phenotypic traits, and 16 metabolites. The expression of specific miRNAs and the abundance of immune cell types were related to the enrichment of immune pathways in the LSL strain. In contrast, more microbial taxa specific to the LB strain were identified, and the abundance of certain microbes strongly correlated with host gut transcripts enriched in immunological and metabolic pathways. Our findings indicate that both strains employ distinct inherent strategies to acquire and maintain their immune and metabolic systems under high-performance conditions. In addition, the study provides a new perspective on a view of the functional biodiversity that emerges during strain selection and contributes to the understanding of the role of host–gut interaction, including immune phenotype, microbiota, gut transcriptome, and metabolome.en
dc.identifier.swb1818861615
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16808
dc.identifier.urihttps://doi.org/10.3389/fgene.2022.858232
dc.language.isoengde
dc.rights.licensecc_byde
dc.source1664-8021de
dc.sourceFrontiers in genetics; Vol. 13 (2022) 858232de
dc.subjectData integration
dc.subjectMixOmics
dc.subjectMicrobiota
dc.subjectmiRNA
dc.subjectmRNA
dc.subjectImmune cells
dc.subjectMetabolites
dc.subjectLaying hen
dc.subject.ddc630
dc.titleMulti-omics reveals different strategies in the immune and metabolic systems of high-yielding strains of laying hensen
dc.type.diniArticle
dcterms.bibliographicCitationFrontiers in genetics, 13 (2022), 858232. https://doi.org/10.3389/fgene.2022.858232. ISSN: 1664-8021
dcterms.bibliographicCitation.issn1664-8021
dcterms.bibliographicCitation.journaltitleFrontiers in genetics
dcterms.bibliographicCitation.volume13
local.export.bibtex@article{Iqbal2022, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16808}, doi = {10.3389/fgene.2022.858232}, author = {Iqbal, Muhammad Arsalan and Reyer, Henry and Oster, Michael et al.}, title = {Multi-Omics Reveals Different Strategies in the Immune and Metabolic Systems of High-Yielding Strains of Laying Hens}, journal = {Frontiers in genetics}, year = {2022}, volume = {13}, }
local.export.bibtexAuthorIqbal, Muhammad Arsalan and Reyer, Henry and Oster, Michael et al.
local.export.bibtexKeyIqbal2022
local.export.bibtexType@article

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