Modulation of hepatic insulin and glucagon signaling by nutritional factors in broiler chicken

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dc.contributor.authorPetrilla, Janka
dc.contributor.authorMátis, Gábor
dc.contributor.authorMackei, Máté
dc.contributor.authorKulcsár, Anna
dc.contributor.authorSebők, Csilla
dc.contributor.authorPapp, Márton
dc.contributor.authorGálfi, Péter
dc.contributor.authorFébel, Hedvig
dc.contributor.authorHuber, Korinna
dc.contributor.authorNeogrády, Zsuzsanna
dc.date.accessioned2024-10-23T12:25:53Z
dc.date.available2024-10-23T12:25:53Z
dc.date.issued2022de
dc.description.abstractInfluencing the endocrine metabolic regulation of chickens by nutritional factors might provide novel possibilities for improving animal health and productivity. This study was designed to evaluate the impact of dietary cereal type (wheat-based (WB) vs. maize-based (MB) diets), crude protein level (normal (NP) vs. lowered (LP)), and sodium (n-)butyrate (1.5 g/kg diet) supplementation (vs. no butyrate) on the responsiveness of hepatic glucagon receptor (GCGR), insulin receptor beta (IRβ) and mammalian target of rapamycin (mTOR) in the phase of intensive growth of chickens. Liver samples of Ross 308 broiler chickens (Gallus gallus domesticus) were collected on day 21 for quantitative real-time polymerase chain reaction and Western blot analyses. Hepatic GCGR and mTOR gene expressions were up-regulated by WB and LP diet. GCGR and IRβ protein level decreased in groups with butyrate supplementation; however, the quantity of IRβ and mTOR protein increased in WB groups. Based on these data, the applied dietary strategies may be useful tools to modulate hepatic insulin and glucagon signaling of chickens in the period of intensive growth. The obtained results might contribute to the better understanding of glycemic control of birds and increase the opportunity of ameliorating insulin sensitivity, hence, improving the production parameters and the welfare of broilers.en
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16819
dc.identifier.urihttps://doi.org/10.3390/vetsci9030103
dc.language.isoengde
dc.rights.licensecc_byde
dc.source2306-7381de
dc.sourceVeterinary sciences; Vol. 9, No. 3 (2022) 103de
dc.subjectInsulin
dc.subjectInsulin receptor beta
dc.subjectGlucagon
dc.subjectHepatic glucagon receptor
dc.subjectMammalian target of rapamycin
dc.subjectButyrate
dc.subjectNon-starch polysaccharides
dc.subjectChicken
dc.subject.ddc630
dc.titleModulation of hepatic insulin and glucagon signaling by nutritional factors in broiler chickenen
dc.type.diniArticle
dcterms.bibliographicCitationVeterinary sciences, 9 (2022), 3, 103. https://doi.org/10.3390/vetsci9030103. ISSN: 2306-7381
dcterms.bibliographicCitation.issn2306-7381
dcterms.bibliographicCitation.issue3
dcterms.bibliographicCitation.journaltitleVeterinary sciences
dcterms.bibliographicCitation.volume9
local.export.bibtex@article{Petrilla2022, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16819}, doi = {10.3390/vetsci9030103}, author = {Petrilla, Janka and Mátis, Gábor and Mackei, Máté et al.}, title = {Modulation of Hepatic Insulin and Glucagon Signaling by Nutritional Factors in Broiler Chicken}, journal = {Veterinary sciences}, year = {2022}, volume = {9}, number = {3}, }
local.export.bibtexAuthorPetrilla, Janka and Mátis, Gábor and Mackei, Máté et al.
local.export.bibtexKeyPetrilla2022
local.export.bibtexType@article

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