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Dietary L-carnitine affects leukocyte count and function in dairy cows around parturition

dc.contributor.authorKononov, Susanne Ursula
dc.contributor.authorMeyer, Jennifer
dc.contributor.authorFrahm, Jana
dc.contributor.authorKersten, Susanne
dc.contributor.authorKluess, Jeannette
dc.contributor.authorBühler, Susanne
dc.contributor.authorWegerich, Anja
dc.contributor.authorRehage, Jürgen
dc.contributor.authorMeyer, Ulrich
dc.contributor.authorHuber, Korinna
dc.contributor.authorDänicke, Sven
dc.date.accessioned2024-10-23T12:25:52Z
dc.date.available2024-10-23T12:25:52Z
dc.date.issued2022de
dc.description.abstractIn early lactation, an energy deficit leading to a negative energy balance (NEB) is associated with increased susceptibility to disease and has been shown to be an important factor during transition in dairy cows. L-carnitine as a key factor in the mitochondrial transport of fatty acids and subsequently for β-oxidation and energy release is known to modulate mitochondrial biogenesis and thus influence metabolism and immune system. In the current study, we characterized hematological changes around parturition and investigated the potential effects of dietary L-carnitine supplementation on immune cell functions. For this approach, dairy cows were assigned either to a control (CON, n = 30) or an L-carnitine group [CAR, n = 29, 25 g rumen-protected L-carnitine per cow and day (d)]. Blood samples were taken from d 42 ante partum (ap) until d 110 post-partum (pp), with special focus and frequent sampling from 0.5 to72 h post-calving to clarify the impact of L-carnitine supplementation on leukocyte count, formation of reactive oxygen species (ROS) in polymorphonuclear cells (PMN) and peripheral mononuclear cells (PBMC) and their phagocytosis activity. Blood cortisol concentration and the capacity of PBMC proliferation was also investigated. All populations of leukocytes were changed during the peripartal period, especially granulocytes showed a characteristic increase up to 4 h pp. L-carnitine supplementation resulted in increased levels of eosinophils which was particularly pronounced one day before to 4 h pp, indicating a possible enhanced support for tissue repair and recovery. Non-supplemented cows showed a higher phagocytic activity in PBMC as well as a higher phagocytic capacity of PMN during the most demanding period around parturition, which may relate to a decrease in plasma levels of non-esterified fatty acids reported previously. L-carnitine, on the other hand, led to an increased efficiency to form ROS in stimulated PMN. Finally, a short period around calving proved to be a sensitive period in which L-carnitine administration was effective.en
dc.identifier.urihttps://hohpublica.uni-hohenheim.de/handle/123456789/16815
dc.identifier.urihttps://doi.org/10.3389/fimmu.2022.784046
dc.language.isoengde
dc.rights.licensecc_byde
dc.source1664-3224de
dc.sourceFrontiers in immunology; Vol. 13 (2022) 784046de
dc.subjectL-carnitine
dc.subjectDairy cow
dc.subjectParturition
dc.subjectPhagocytosis
dc.subjectROS production
dc.subjectLeukocyte functionality
dc.subject.ddc630
dc.titleDietary L-carnitine affects leukocyte count and function in dairy cows around parturitionen
dc.type.diniArticle
dcterms.bibliographicCitationFrontiers in Immunology, 13 (2022), 784046. https://doi.org/10.3389/fimmu.2022.784046. ISSN: 1664-3224
dcterms.bibliographicCitation.issn1664-3224
dcterms.bibliographicCitation.journaltitleFrontiers in Immunology
dcterms.bibliographicCitation.volume13
local.export.bibtex@article{Kononov2022, url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16815}, doi = {10.3389/fimmu.2022.784046}, author = {Kononov, Susanne Ursula and Meyer, Jennifer and Frahm, Jana et al.}, title = {Dietary L-Carnitine Affects Leukocyte Count and Function in Dairy Cows Around Parturition}, journal = {Frontiers in Immunology}, year = {2022}, volume = {13}, }
local.export.bibtexAuthorKononov, Susanne Ursula and Meyer, Jennifer and Frahm, Jana et al.
local.export.bibtexKeyKononov2022
local.export.bibtexType@article

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