A new version of this entry is available:
Loading...
Article
2025
High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study
High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study
Abstract (English)
Background: Disease-related inflammation affects chemosensory signaling, but knowledge on the impact of exercise-induced low-grade inflammation on taste function remains scarce. Here we hypothesized that intense habitual physical activity modifies sweet taste perception via increased cytokine release.
Methods: In an observational human study we compared participants (m/f) engaging in high (n = 34) and low (n = 31) levels of habitual physical activity. Salivary IL-6 and urinary 8-iso-prostaglandin F2α levels, body composition, sucrose recognition threshold, preference and consumption of sweet foods, size and area of fungiform papillae as well as selected hormones regulating food intake were recorded. Statistical analysis was conducted using Principal Component Analysis (PCA) followed by Student’s t-tests and multiple regression models.
Results: The PCA summarized the main outcome variables to two principal components (PC). PC1 was primarily influenced by body composition and fungiform papillae markers, while sucrose recognition thresholds, sweet food consumption, and IL-6 levels strongly contributed to PC2. Compared to the low activity group, the high activity group showed on average an increased sucrose recognition threshold (+ 35.8 ± 12.8%), increased IL-6 concentrations (+ 25.6 ± 10.9%), higher consumptions of sweet foods (+ 18.8 ± 4.9%) and decreased number (24.8 ± 4.9%) and area (-29.8 ± 6.4%) of fungiform papillae.
Conclusions: The association between modified sweet taste function markers and increased IL-6 levels suggests that inflammatory processes may contribute to exercise-related changes in chemosensory perception.
File is subject to an embargo until
This is a correction to:
A correction to this entry is available:
This is a new version of:
Other version
Notes
Publication license
Publication series
Published in
Nutrition & metabolism, 22 (2025), 1, 148.
https://doi.org/10.1186/s12986-025-01050-8.
ISSN: 1743-7075
London : BioMed Central
Other version
Faculty
Institute
Examination date
Supervisor
Cite this publication
Kimmeswenger, I., Gaider, M., Doppelmayer, K., Ley, J. P., & Lieder, B. (2025). High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study. Nutrition & metabolism, 22(1). https://doi.org/10.1186/s12986-025-01050-8
Edition / version
Citation
DOI
ISSN
ISBN
Language
English
Publisher
Publisher place
Classification (DDC)
610 Medicine and health
Original object
University bibliography
Standardized keywords (GND)
Sustainable Development Goals
BibTeX
@article{Kimmeswenger2025,
doi = {10.1186/s12986-025-01050-8},
author = {Kimmeswenger, Isabella and Gaider, Marlies and Doppelmayer, Kevin et al.},
title = {High physical activity is associated with decreased fungiform papillae area and number, elevated sucrose recognition thresholds, and increased IL-6 levels: an observational human study},
journal = {Nutrition & Metabolism},
year = {2025},
volume = {22},
number = {1},
}