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Browsing by Subject "Omega-3 fatty acids"

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    Die Mikroalge Phaeodactylum tricornutum : Bioverfügbarkeit, Sicherheit und potenzieller gesundheitlicher Nutzen für die humane Ernährung
    (2023) Kopp, Lena Janine; Bischoff, Stephan C.
    The dissertation by Lena Kopp investigated the suitability of the microalga Phaeodactylum tricornutum (PT) for human nutrition. PT contains essential nutrients such as the long-chain omega-3 fatty acid eicosapentaenoic acid (EPA), which is otherwise found mainly in fish. In addition, PT contains a high content of other nutrients such as proteins, carotenoids (in particular fucoxanthin), vitamins and β-glucans, which have nutritive and therapeutic potential. Clinical and animal studies have shown that the PT biomass ingestion is safe and has potential health effects, such as anti-inflammatory and prebiotic effects. The results suggest that PT can be used as a food for human nutrition with possible health-promoting effects.
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    Oral intake of the microalgae Nannochloropsis oceanica, Chlorella vulgaris, or Phaeodactylum tricornutum improves metabolic conditions in hypercaloric-fed mice
    (2024) Kopp, Lena; Seethaler, Benjamin; Neumann, Ulrike; Bischoff, Stephan C.
    Diet-induced metabolic load is associated with excess body weight and liver steatosis. Here, selected microalgae, known to contain bioactive nutrients, were studied for beneficial metabolic effects in a mouse model of liver steatosis. Adult mice (8 per group) were fed either a Western-style diet (WSD) or a control diet +/ 15 % of the microalgae Chlorella vulgaris (CV), Nannochloropsis oceanica (NO), or Phaeodactylum tricornutum (PT) for 12 weeks. We evaluated liver fat content and liver damage, as well as fecal microbiota and lipopolysaccharide (LPS) translocation. NO supplementation to a WSD reduced the grade of liver steatosis (from 17 % to 4.7 %, p < 0.002), the liver damage score (p < 0.001), and LPS translocation (p < 0.001). PT had similar effects on liver damage score (p < 0.001) and LPS translocation (p < 0.001). CV supplementation reduced LPS translocation (p < 0.001). In conclusion, dietary supplementation of microalgae may be a novel sustainable approach to combat metabolic loads.