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Article
2023
Emerging principles of primary cilia dynamics in controlling tissue organization and function
Emerging principles of primary cilia dynamics in controlling tissue organization and function
Abstract (English)
Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context‐dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell‐ and tissue‐specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.
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The EMBO journal, 42 (2023), 21, e113891.
https://doi.org/10.15252/embj.2023113891.
ISSN: 1460-2075
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English
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570 Biology
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Free keywords
Cilia dynamics Ciliary signaling Cilium disassembly Primary cilia Tissue organization
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Sustainable Development Goals
BibTeX
@article{Gopalakrishnan2023,
url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16165},
doi = {10.15252/embj.2023113891},
author = {Gopalakrishnan, Jay and Feistel, Kerstin and Friedrich, Benjamin M et al.},
title = {Emerging principles of primary cilia dynamics in controlling tissue organization and function},
journal = {The EMBO journal},
year = {2023},
volume = {42},
number = {21},
}