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Article
2021
Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study
Abstract (English)
Metabolic consequences of an energy and protein rich diet can compromise metabolic health of cattle by promoting a pro-inflammatory phenotype. Laminitis is a common clinical sign, but affected metabolic pathways, underlying pathophysiology and causative relationships of a systemic pro-inflammatory phenotype are unclear. Therefore, the aim of this study was to elucidate changes in metabolome profiles of 20 months old Holstein bulls fed a high energy and protein diet and to identify novel metabolites and affected pathways, associated with diet-related laminitis. In a randomized controlled feeding trial using bulls fed a high energy and protein diet (HEP; metabolizable energy [ME] intake 169.0 ± 1.4 MJ/day; crude protein [CP] intake 2.3 ± 0.02 kg/day; calculated means ± SEM; n = 15) versus a low energy and protein diet (LEP; ME intake 92.9 ± 1.3 MJ/day; CP intake 1.0 ± 0.01 kg/day; n = 15), wide ranging effects of HEP diet on metabolism were demonstrated with a targeted metabolomics approach using the AbsoluteIDQ p180 kit (Biocrates Life Sciences). Multivariate statistics revealed that lower concentrations of phosphatidylcholines and sphingomyelins and higher concentrations of lyso-phosphatidylcholines, branched chain amino acids and aromatic amino acids were associated with an inflammatory state of diet-related laminitis in Holstein bulls fed a HEP diet. The latter two metabolites share similarities with changes in metabolism of obese humans, indicating a conserved pathophysiological role. The observed alterations in the metabolome provide further explanation on the underlying metabolic consequences of excessive dietary nutrient intake.
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Scientific reports, 11 (2021), 1, 12735.
https://doi.org/10.1038/s41598-021-92163-6.
ISSN: 2045-2322
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630 Agriculture
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Sustainable Development Goals
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@article{Bäßler2021,
url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16390},
doi = {10.1038/s41598-021-92163-6},
author = {Bäßler, Sonja Christiane and Kenéz, Ákos and Scheu, Theresa et al.},
title = {Association between alterations in plasma metabolome profiles and laminitis in intensively finished Holstein bulls in a randomized controlled study},
journal = {Scientific reports},
year = {2021},
volume = {11},
number = {1},
}