A new version of this entry is available:
Loading...
Article
2022
Potential modulation of inflammation by probiotic and omega-3 supplementation in elderly with chronic low-grade inflammation - a randomized, placebo-controlled trial
Potential modulation of inflammation by probiotic and omega-3 supplementation in elderly with chronic low-grade inflammation - a randomized, placebo-controlled trial
Abstract (English)
Probiotic and omega-3 supplements have been shown to reduce inflammation, and dual supplementation may have synergistic health effects. We investigated if the novel combination of a multi-strain probiotic (containing B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM, and B. lactis Bl-04) alongside omega-3 supplements reduces low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) in elderly participants in a proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330). In this case, 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0–73.8) underwent an intervention with the dual supplement (n = 37) or placebo (n = 39) for eight weeks. In addition to hs-CRP, cytokine levels and intestinal permeability were also assessed at baseline and after the eight-week intervention. No significant difference was seen for hs-CRP between the dual supplement group and placebo. However, interestingly, supplementation did result in significant increases in the level of the anti-inflammatory marker IL-10. In addition, dual supplementation increased levels of valeric acid, further suggesting the potential of the supplements in reducing inflammation and conferring health benefits. Together, the results suggest that probiotic and omega-3 dual supplementation exerts modest effects on inflammation and may have potential use as a non-pharmacological treatment for low-grade inflammation in the elderly.
File is subject to an embargo until
This is a correction to:
A correction to this entry is available:
This is a new version of:
Notes
Publication license
Publication series
Published in
Nutrients, 14 (2022), 19, 3998.
https://doi.org/10.3390/nu14193998.
ISSN: 2072-6643
Other version
Faculty
Institute
Examination date
Supervisor
Edition / version
Citation
DOI
ISSN
ISBN
Language
English
Publisher
Publisher place
Classification (DDC)
610 Medicine and health
Collections
Original object
Standardized keywords (GND)
Sustainable Development Goals
BibTeX
@article{Tingö2022,
url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16558},
doi = {10.3390/nu14193998},
author = {Tingö, Lina and Hutchinson, Ashley N. and Bergh, Cecilia et al.},
title = {Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial},
journal = {Nutrients},
year = {2022},
volume = {14},
number = {19},
}