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Article
2023
Uncovering the relationship between selenium status, age, health, and dietary habits: Insights from a large population study including nonagenarian offspring from the MARK-AGE project
Uncovering the relationship between selenium status, age, health, and dietary habits: Insights from a large population study including nonagenarian offspring from the MARK-AGE project
Giacconi, Robertina Piacenza, Francesco Aversano, Valentina Zampieri, Michele Bürkle, Alexander Villanueva, María Moreno Dollé, Martijn E.T. Jansen, Eugène Grune, Tilman Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Weinberger, Birgit Sikora, Ewa Toussaint, Olivier Debacq-Chainiaux, Florence Stuetz, Wolfgang Slagboom, Pieternella Eline Bernhardt, Jürgen Fernández-Sánchez, Maria Luisa Provinciali, Mauro Malavolta, Marco
Abstract (English)
An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation.
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Nutrients, 15 (2023), 9, 2182.
https://doi.org/10.3390/nu15092182.
ISSN: 2072-6643
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610 Medicine and health
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Sustainable Development Goals
BibTeX
@article{Giacconi2023,
url = {https://hohpublica.uni-hohenheim.de/handle/123456789/16259},
doi = {10.3390/nu15092182},
author = {Giacconi, Robertina and Piacenza, Francesco and Aversano, Valentina et al.},
title = {Uncovering the relationship between selenium status, age, health, and dietary habits: Insights from a large population study including nonagenarian offspring from the MARK-AGE project},
journal = {Nutrients},
year = {2023},
volume = {15},
number = {9},
}